Characteristics Of Pharmaceutical Intermediates

At present, the quinolone antibacterial drugs that have been developed and put into mass production in my country’s chemical and pharmaceutical intermediates mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, fleroxacin and so on. Among them, Norfloxacin, Ciprofloxacin, and Ofloxacin have the largest production volume, accounting for 98% of the total domestic production of fluoroquinolone antibacterial drugs.

Quinolones are generally synthesized from fluorine-containing benzene ring to synthesize fluorine-containing quinoline compounds and then condensed with piperazine (or methylpiperazine). Due to the rich reserves of fluorite in my country, it is one of the countries with the largest production of fluorine-containing drugs and intermediates in the world, with more than 80% of fluorine-containing intermediates for export. On the whole, the development of fluorobenzene intermediates in China is relatively early, and the current production capacity is generally surplus; the development of trifluorotoluene intermediates is relatively late, and the development speed has been relatively fast in recent years; and for heterocyclic aromatic compounds, especially fluorine-containing pyridines Currently, only a few research units and manufacturers in China have the synthesis technology of fluorine-containing pyridine intermediates. Therefore, fluorine-containing pyridine intermediates will become one of the main directions of domestic fluorine-containing intermediate research and development in the next few years. China has become the world’s largest producer of antipyretics and analgesics. The output of aspirin, paracetamol, analgin and other varieties exceeds 10,000 tons, and the output of phenacetin, aminopyrine, and antipyrine exceeds 1,000. Ton. At present, the output of antipyretic and analgesics in my country is growing rapidly, and it is expected to increase at a rate of about 8% in the future. The production of intermediates for the production of antipyretic and analgesics is large and there are many manufacturers. With the growth of antipyretic and analgesic drugs, their intermediates have also made considerable progress.

Post time: Apr-09-2021